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1.
Vet Med Sci ; 10(2): e1402, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38450948

RESUMO

An 11-year-old, female-neutered beagle was presented with a growing soft tissue mass arising within the deep tissues of the left cranial cervical region. At presentation, facial asymmetry was evident along with palpable lymphadenomegaly. Magnetic resonance imaging demonstrated a locally invasive cervical mass with intracranial invasion through focal osteolysis of the occipital bone. After antihistamine administration, cytology confirmed mast cell tumour (MCT) with metastasis to local lymph nodes and liver. The owner chose to pursue lomustine and prednisolone, which were dispensed, but, before home administration, prolonged seizures/status epilepticus occurred prompting euthanasia. Postmortem examination confirmed a high-grade MCT associated with, and infiltrating through, muscle, calvarium, dura mata, leptomeninges and the underlying brain. We present the clinical, imaging, and pathological findings of an unprecedented case of extracranial MCT tumour causing osteolysis of an imperforate flat bone (occipital bone) and intracranial invasion.


Assuntos
Doenças do Cão , Neoplasias , Osteólise , Feminino , Animais , Cães , Mastócitos , Osteólise/veterinária , Encéfalo , Fígado , Neoplasias/veterinária , Doenças do Cão/diagnóstico por imagem
2.
Vet Med Sci ; 10(3): e1431, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38549360

RESUMO

A 10-year-old Cocker spaniel presented with lethargy. Triple-phase computed tomography was obtained with a contrast test bolus at the level of porta hepatis, which revealed a right lower abdominal mass. The mass was not connected to other abdominal organs; however, a linear structure was observed connecting the splenic hilum to the mass, which was suspected to be the feeding vessel. The arterial phase image was obtained again with a contrast bolus at the level of the celiac artery. A prominent contrast-enhanced feeding artery originating from the splenic artery to the mass was observed. Histopathology confirmed an accessory splenic hemangiosarcoma.


Assuntos
Doenças do Cão , Hemangiossarcoma , Neoplasias Esplênicas , Cães , Animais , Hemangiossarcoma/diagnóstico por imagem , Hemangiossarcoma/veterinária , Neoplasias Esplênicas/diagnóstico por imagem , Neoplasias Esplênicas/veterinária , Tomografia Computadorizada por Raios X/veterinária , Fígado , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/patologia
3.
PLoS One ; 19(3): e0300827, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38547236

RESUMO

INTRODUCTION: Degenerative mitral valve disease (DMVD) is the most common canine heart disease with a high predisposition in Cavalier King Charles Spaniels (CKCSs). Mitral regurgitation related to DMVD can lead to left atrial (LA) dilation, which is associated with survival time. Left-atrial-to-aortic (LA:Ao) ratio assessed by two-dimensional echocardiography is commonly used to evaluate LA size. The objectives of this prospective observational study were therefore 1) to compare different echocardiographic methods (i.e., monoplane and biplane Simpson's methods of discs (SMOD) and area-length methods (ALM)) in evaluating LA volume (LAvol) in CKCSs, 2) to assess LA volumes according to DMVD severity and, 3) compare the ability of LAvol and LA:Ao ratio to identify LA enlargement in CKCSs with subclinical DMVD (i.e., American College of Veterinary Internal Medicine (ACVIM) stage B). MATERIALS AND METHODS: 155 CKCSs, either healthy or affected by DMVD, were recruited. Variability and concordance between volumetric methods were evaluated. Values were analyzed according to 2019 ACVIM stages. RESULTS: All Lin's concordance correlation coefficients regarding intra- and inter-observer variability were considered as very good to excellent. Monoplane methods and ALM produced higher values of LAvol than biplane methods and SMOD, respectively. The upper limit of normal end-systolic LAvol/body weight (LASvol/BW) was defined as 0.90 mL/kg. Left atrial volumes significantly increased with ACVIM stages. Additionally, 37% of stage B1 CKCSs demonstrated LA enlargement using LASvol/BW assessment, with significantly lower LASvol/BW values in dogs with regurgitation fraction ≤30% than in others (p<0.01). CONCLUSION: In CKCSs, LAvol methods are not interchangeable. In ACVIM stage B CKCSs, LAvol quantification is more effective to detect LA enlargement than LA linear measurements.


Assuntos
Doenças do Cão , Insuficiência da Valva Mitral , Animais , Cães , Aorta/diagnóstico por imagem , Dilatação , Doenças do Cão/diagnóstico por imagem , Ecocardiografia/métodos , Átrios do Coração/diagnóstico por imagem , Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/veterinária , Estudos Prospectivos
4.
BMC Vet Res ; 20(1): 115, 2024 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-38521902

RESUMO

BACKGROUND: Swelling of the perineal region in male dogs is most commonly caused by a perineal hernia. Clinical signs associated with perineal hernia are constipation, tenesmus or stranguria. This case report documents a rare cause of perineal swelling created by the growth of a malignant tumour leading to urethral obstruction and subsequent stranguria. CASE PRESENTATION: An 11-year-old neutered male German Shepherd was presented for swelling in the perineal region and stranguria for three days. Complete blood count and serum biochemistry were unremarkable. Ultrasound revealed a heterogeneous mass in the perineal region. Retrograde urethrography showed a severe narrowing of the urethra caudal to the pelvis. A fine-needle aspirate of the mass was highly suspicious for liposarcoma. Staging was performed by computed tomography (CT) of the thorax and abdomen. Total penile amputation in combination with pubic-ischial pelvic osteotomy, transposition of the remaining urethra through the inguinal canal, V-Y-plasty cranial to the prepuce and preputial urethrostomy were performed to remove the tumour. Histopathology confirmed a well-differentiated liposarcoma with complete histological margins. Six months after the surgery the dog was doing well and there were no signs indicating local tumour recurrence. CONCLUSIONS: Wide surgical excision is generally recommended for soft tissue sarcomas, however this is sometimes not feasible for large tumours. In the case reported here, tumour resection was achieved by a combination of several surgical techniques with a good clinical outcome.


Assuntos
Doenças do Cão , Lipossarcoma , Obstrução Uretral , Cães , Masculino , Animais , Obstrução Uretral/etiologia , Obstrução Uretral/cirurgia , Obstrução Uretral/veterinária , Uretra/patologia , Pênis/patologia , Lipossarcoma/complicações , Lipossarcoma/cirurgia , Lipossarcoma/veterinária , Hérnia/patologia , Hérnia/veterinária , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/etiologia , Doenças do Cão/cirurgia
5.
Vet Q ; 44(1): 1-7, 2024 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38497337

RESUMO

Pancreatic alpha amylase (P-AMY) is used as a biomarker of acute pancreatitis (AP) in human medicine. To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group (n = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation. Evaluation of the canine AP severity (CAPS) score was performed. The control group (n = 38) was composed of normal dogs without any abnormalities in clinical findings, blood exams or diagnostic imaging. The correlation of P-AMY with cPL was confirmed by Pearson's correlation analysis (r = 0.564, p < .001). The sensitivity and specificity for the most appropriate cut-off values of P-AMY were recorded similar to the values of DGGR. The dogs with AP and CAPS ≥11 had significantly higher serum P-AMY (p = .016) contrary to DGGR lipase and cPL. Furthermore, there was a significant difference in the median P-AMY dependent on the presence of systemic inflammatory response syndrome (p = .001). P-AMY showed similar level of diagnostic accuracy along with sensitivity and specificity compared to DGGR lipase. In addition, P-AMY showed a significant association with CAPS score, contrary to cPL and DGGR lipase. Along with other biomarkers associated with AP, P-AMY has the potential of usefulness as a supportive diagnostic and prognostic biomarker of AP in dogs.


Assuntos
Doenças do Cão , Pancreatite , Cães , Animais , Humanos , Pancreatite/diagnóstico , Pancreatite/veterinária , Projetos Piloto , alfa-Amilases Pancreáticas , Doença Aguda , Doenças do Cão/diagnóstico por imagem , Lipase , Biomarcadores
6.
Vet Radiol Ultrasound ; 65(2): 145-148, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38297959

RESUMO

A 12-year-old female spayed Beagle was referred for investigation of exophthalmos. CT revealed a well-defined, retrobulbar mass causing rostro-dorsal displacement of the left globe. The mass had a mildly heterogeneous precontrast soft tissue attenuation with mild heterogeneous enhancement following iohexol administration. The mass was surgically removed en bloc with an orbital exenteration. Histopathology confirmed the mass to be a hibernoma, a benign tumor of brown adipose tissue. Hibernomas have CT characteristics consistent with both benign and malignant adipose tumors and may be underrecognized by radiologists.


Assuntos
Doenças do Cão , Lipoma , Feminino , Cães , Animais , Tomografia Computadorizada por Raios X/veterinária , Lipoma/diagnóstico por imagem , Lipoma/cirurgia , Lipoma/veterinária , Olho , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia
7.
Vet Radiol Ultrasound ; 65(2): 157-169, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38318920

RESUMO

Caudal protrusion of pelvic organs and dilatation and deviation of the rectum with perineal hernia (PH) have not previously been studied using CT, and it is not known how completely the changes normalize after PH repair. Objectives of this prospective experimental case series were to evaluate the dimensions and shape of the rectum and the volume, location, and other features (enhancement pattern, presence of cysts, and mineralizations) of the prostate of 66 dogs on CT before and 3 months after PH repair. The rectal cross-sectional areas were measured at intrapelvic and caudal locations, and the shape was categorized as straight, deviated, flexure, or caudal fold on dorsal images. According to paired samples t-tests, the caudal rectal dimensions were significantly larger (P < .001) than the intrapelvic dimensions both before and 3 months after PH repair, and according to linear mixed models, the intrapelvic dimensions increased significantly (P < .001) after repair. Before PH repair, the most common rectal shape was flexure (69.2%); after repair, the number of dogs having a straight rectum increased significantly (P < .001) according to the McNemar paired-samples proportion test. We were also able to show that rectal dimensions increased after PH repair despite straightening in most dogs. According to the linear mixed model, prostate ratio volume, and according to Wilcoxon signed ranks test, the number of prostates with intraprostatic cysts decreased significantly (both P < .001) after PH repair, but the proportion of prostates located in the caudal or perineal area did not. Small mineralizations remained in some dogs.


Assuntos
Cistos , Doenças do Cão , Masculino , Cães , Animais , Reto/diagnóstico por imagem , Reto/cirurgia , Próstata , Estudos Prospectivos , Tomografia Computadorizada por Raios X , Cistos/veterinária , Hérnia/veterinária , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia
8.
Vet Radiol Ultrasound ; 65(2): 149-156, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38318990

RESUMO

The accurate diagnosis of portovascular anomalies has been facilitated by improvements in diagnostic imaging technology. In humans, hepatic arterial blood flow changes in response to the reduction in portal blood flow. The hepatic arterial buffer response characterizes an intrinsic regulatory mechanism in response to reduced portal venous blood flow, which results in hepatic arterial enlargement. At the authors' institution, enlargement of the hepatic artery has been anecdotally observed in a population of dogs with extrahepatic portosystemic shunting, consistent with previous literature that documents variability in hepatic arterial size. In this retrospective, blinded, analytical study, a hepatic artery:aorta (Ha:Ao) ratio was assessed on CT studies from 112 dogs, with (n = 43) and without (n = 69) an extrahepatic congenital portosystemic shunt in order to compare the hepatic artery size independent of body weight between the two populations. A significant increase in the Ha:Ao ratio was documented in dogs with an extrahepatic portosystemic shunt (EHPSS) compared with those dogs with no EHPSS independent of the location of shunt insertion into the systemic circulation (P < .001). Three cases had repeat CT after surgery, and all had Ha:Ao ratio reductions following treatment. The authors propose that this may be an additional imaging feature observed in dogs with an EHPSS.


Assuntos
Doenças do Cão , Derivação Portossistêmica Transjugular Intra-Hepática , Humanos , Cães , Animais , Sistema Porta/diagnóstico por imagem , Sistema Porta/cirurgia , Sistema Porta/anormalidades , Artéria Hepática/diagnóstico por imagem , Estudos Retrospectivos , Derivação Portossistêmica Transjugular Intra-Hepática/veterinária , Veia Porta/diagnóstico por imagem , Veia Porta/cirurgia , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia , Doenças do Cão/congênito
9.
J Vet Intern Med ; 38(2): 1083-1091, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38328940

RESUMO

BACKGROUND: Cerebrovascular accidents (CVAs) in dogs are diagnosed using magnetic resonance imaging (MRI). This modality is sometimes unavailable, and CVAs can resemble other lesions on MRI. D-dimer concentration and thromboelastography (TEG) are utilized in human medicine in addition to diagnostic imaging to support diagnosis of CVAs, but their use in veterinary patients has not been assessed. OBJECTIVE: Assess utility of blood D-dimer concentration and TEG in supporting the imaging diagnosis of CVAs in dogs. ANIMALS: Sixty-eight client-owned dogs with neurologic signs that had brain MRI and D-dimer concentration or TEG performed. METHODS: Multicenter, retrospective study. The incidence of abnormal D-dimer concentration or TEG was compared between patients with MRI evidence of CVA and a control population. Analysis methods included Fisher's exact test or Chi-squared test for association and comparison of independent proportions. RESULTS: Neither D-dimer concentration nor TEG was significantly associated with a CVA (P = .38 and .2, respectively). D-dimer testing was performed in a low-risk population and showed low sensitivity (30.8%; 95% confidence interval [CI], 10%-61%) and high specificity (86.4%; 95% CI, 64%-96%) for CVA diagnosis. Thromboelastography was performed in a high-risk population and showed moderate sensitivity (64.3%; 95% CI, 44%-81%) and specificity (66.7%; 95% CI, 24%-94%) for CVA diagnosis. Abnormal D-dimer concentration or TEG were not helpful in differentiating hemorrhagic from ischemic stroke (P = .43 and .41, respectively). CONCLUSIONS: Although blood D-dimer concentration or TEG alone are not diagnostic of CVAs in dogs, a positive D-dimer result supports additional testing for CVA.


Assuntos
Doenças do Cão , Acidente Vascular Cerebral , Animais , Cães , Doenças do Cão/diagnóstico por imagem , Produtos de Degradação da Fibrina e do Fibrinogênio , Estudos Retrospectivos , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/veterinária , Acidente Vascular Cerebral/epidemiologia , Tromboelastografia/veterinária
10.
Vet Rec ; 194(6): e3857, 2024 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-38379246

RESUMO

BACKGROUND: Brachycephalic dogs with pulmonary stenosis are known to have a higher incidence of concurrent coronary artery abnormalities than non-brachycephalic breeds, which increases risk when performing balloon valvuloplasty. The use of ECG-gated CT angiography has been reported for the evaluation of coronary arteries in normal dogs and dogs with pulmonary stenosis. The purpose of this study was to report findings of coronary artery origination and morphology of main branches using ECG-gated CT angiography in brachycephalic dogs with pulmonary stenosis. METHODS: An ECG-gated CT angiographic protocol was used to image coronary artery anatomy in nine brachycephalic dogs with pulmonary stenosis. Images were assessed for quality as well as coronary artery morphology by one veterinary radiologist, one veterinary cardiologist and one veterinary radiology resident. RESULTS: All nine dogs had good to excellent image quality. Coronary artery anomalies were identified in three of nine dogs: one R2A anomaly, one L2A anomaly and one L2C anomaly. Two dogs were assessed to be poor balloon valvuloplasty candidates based on CT angiographic images. LIMITATION: Coronary artery morphology was not confirmed via postmortem examination in all patients. CONCLUSION: ECG-gated CT angiography is a minimally invasive imaging modality capable of diagnosing various coronary artery anomalies in brachycephalic dogs with pulmonary stenosis and aiding in the determination of patient candidacy for balloon valvuloplasty.


Assuntos
Craniossinostoses , Doenças do Cão , Cardiopatias Congênitas , Estenose da Valva Pulmonar , Cães , Animais , Angiografia por Tomografia Computadorizada/veterinária , Vasos Coronários , Angiografia , Estenose da Valva Pulmonar/diagnóstico por imagem , Estenose da Valva Pulmonar/veterinária , Cardiopatias Congênitas/veterinária , Craniossinostoses/veterinária , Eletrocardiografia/veterinária , Doenças do Cão/diagnóstico por imagem
11.
J Vet Intern Med ; 38(2): 904-912, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38391152

RESUMO

BACKGROUND: Syringomyelia (SM) and myxomatous mitral valve disease (MMVD) are highly prevalent in Cavalier King Charles spaniels (CKCS). Cardiac status in CKCS with and without SM is currently unknown. OBJECTIVES: To investigate the association between SM and MMVD severity in CKCS and CKCS with SM with and without clinical signs of SM. ANIMALS: Fifty-five CKCS: 40 with SM (22 symptomatic and 18 asymptomatic) and 15 without SM. METHODS: A combined retrospective and prospective study. MRI and echocardiography were used to diagnose SM and MMVD, respectively. The association between SM and MMVD severity (left ventricle internal diameter in diastole normalized to bodyweight [LVIDDN] and left atrium to aortic ratio [LA/Ao]) were tested using multivariable linear regression analysis adjusting for sex and age. RESULTS: Overall, no significant difference in LVIDDN and LA/Ao was found between CKCS with or without SM. However, CKCS with symptomatic SM had significantly smaller LVIDDN (1.45 [1.30-1.50]) (median [IQR]) and LA/Ao (1.20 [1.10-1.28]) compared to CKCS with asymptomatic SM (1.60 [1.50-1.90] and 1.40 [1.20-1.75]) as well as CKCS without SM (0.24 [0.03-0.45] and 0.30 [0.05-0.56]) (all P values <.03). CONCLUSIONS AND CLINICAL IMPORTANCE: An association between MMVD and SM was not confirmed in this cohort of CKCS, indicating that MMVD and SM do not co-segregate. However, CKCS with symptomatic SM had smaller left ventricle and atrial size compared to CKCS with asymptomatic SM and CKCS without SM.


Assuntos
Doenças do Cão , Doenças das Valvas Cardíacas , Siringomielia , Humanos , Cães , Animais , Valva Mitral/diagnóstico por imagem , Estudos Retrospectivos , Estudos Prospectivos , Siringomielia/diagnóstico por imagem , Siringomielia/veterinária , Doenças do Cão/diagnóstico por imagem , Doenças das Valvas Cardíacas/veterinária
12.
Vet Radiol Ultrasound ; 65(2): 170-180, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38339855

RESUMO

Computed tomography is frequently used to stage canine mast cell tumors (MCTs). The aims of this prospective, observational study were to describe the CT features of MCTs, to evaluate the performance of CT in detecting additional or incidental MCTs, to distinguish between cutaneous (cMCT) or subcutaneous (scMCT) MCTs, and to identify one or multiple sentinel lymph nodes (SLNs) by indirect CT lymphography (ICTL). Seventy-two dogs affected by 111 MCTs were included. The recorded parameters were: shape, size, attenuation (Hounsfield units [HU]), location (cutaneous or subcutaneous), and presence of fat stranding. The SLNs were compared with the regional lymph nodes and supplementary MCTs were registered. Mast cell tumors mostly appeared with well-defined margins (89%), round/oval shape (71%), homogeneous enhancement (90%) with a mean postcontrast density of 62.0 ± 23.4 HU and associated with fat stranding (43%). Cutaneous mast cell tumors were more frequently round (P = .003), whereas scMCTs were oval (P = .011) with a larger mean maximal diameter (2.91 ± 1.57 cm vs 1.46 ± 1.28 cm, P = .002) and more feeding vessels (77% vs 39% P = .044). Compared with histopathology, CT accuracy in differentiating cMCTs and sMCTs was 57%, with an interobserver agreement of 88% (three reviewers). Indirect CT lymphography showed the SLN in 82 of 85 (97%) cases, 32% of them not corresponding to the regional node. CT showed additional or incidental MCTs in 23 of 72 (32%) dogs. In conclusion, the common CT appearance of canine cMCTs and scMCTs is reported with some statistical differences between the two categories. CT is useful in identifying clinically undetected MCTs and SLNs, although it shows low accuracy in distinguishing between cMCT and scMCT.


Assuntos
CME-Carbodi-Imida , Doenças do Cão , Neoplasias , Linfonodo Sentinela , Animais , Cães , CME-Carbodi-Imida/análogos & derivados , Doenças do Cão/diagnóstico por imagem , Linfonodos/diagnóstico por imagem , Linfografia/veterinária , Linfografia/métodos , Mastócitos , Neoplasias/veterinária , Estudos Prospectivos , Tomografia Computadorizada por Raios X/veterinária , Tomografia Computadorizada por Raios X/métodos
13.
PLoS One ; 19(2): e0293363, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38324604

RESUMO

Atlanto-axial instability is a common disease that affects toy-breed dogs. Most cases of atlanto-axial instability are congenital. Furthermore, patients with atlanto-axial instability are predisposed to other concurrent diseases. Therefore, this study aimed to retrospectively determine the presence of concurrent diseases in cases with atlanto-axial instability using imaging data and analyze the relationship between clinical parameters and the incidence of complex malformations. The clinical data and imaging findings of 41 toy-breed dogs diagnosed with atlanto-axial instability were analyzed using their medical records and imaging data. Occipital dysplasia (17/27), atlanto-occipital overlapping (22/34), dens dysplasia (27/41), Chiari-like malformation (8/34), syringomyelia (5/34), lateral ventricular enlargement (20/36), and intracranial arachnoid cyst (5/35) were observed in patients with atlanto-axial instability. The body weight of the patients in the groups with atlanto-occipital overlapping and lateral ventricular enlargement was lower than that of those in the groups without these diseases (1.78 ± 0.71 vs 2.71 ± 1.15 kg, P = 0.0269, 1.60 ± 0.40 vs 2.75 ± 1.08 kg, P = 0.001, respectively). Furthermore, when the correlation between the total number of concurrent diseases and the age at onset and body weight was examined, it became clear that lower body weight was associated with the incidence of a greater number of concurrent diseases. Thus, the findings of this study suggest that toy-breed dogs are more likely to present with complex malformations and should be evaluated carefully with additional examinations and treatment methods.


Assuntos
Articulação Atlantoaxial , Doenças do Cão , Siringomielia , Humanos , Cães , Animais , Estudos Retrospectivos , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/epidemiologia , Doenças do Cão/congênito , Siringomielia/diagnóstico por imagem , Siringomielia/epidemiologia , Siringomielia/veterinária , Exame Físico , Peso Corporal , Articulação Atlantoaxial/diagnóstico por imagem
14.
BMC Vet Res ; 20(1): 44, 2024 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-38310231

RESUMO

BACKGROUND: A multimodal approach for diagnostic tests under anesthesia is required to diagnose nasal cavity pathology (NP) reliably in dogs. Blood test results may provide clues to the suspected NP. METHODS: This prospective blinded study assessed 72 dogs with chronic nasal discharge due to NPs, and 10 healthy dogs as the control group (CG). NPs were diagnosed using whole-body computed tomography (CT), upper airway endoscopy, examination of nasal mucosal swabs by bacterial and fungal culture, and histopathological examination of nasal mucosa biopsies. The exclusion criteria were the presence of any additional diseases or corticosteroid pre-treatment. In consideration of these exclusion criteria, 55 dogs entered the study. Dogs were classified into benign (benign tumors, idiopathic rhinitis (IR), and others) and malignant (carcinomas and sarcomas) NP groups. Blood count and blood chemistry tests were performed. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and albumin-to-globulin ratio (AGR) were calculated and compared. RESULTS: 25 dogs with malignant NP (13 and 12 with carcinomas and sarcomas, respectively) and 30 dogs with benign NP (seven with benign tumors,13 with IR, and 10 others) were included. In general, in dogs with NP there were only slight abnormalities in complete blood count. However, PLR was significantly higher in dogs with malignant NP (carcinoma and sarcoma) than in those with benign NP and in the CG. Compared with the CG, the NLR was significantly increased in all dogs with NP, and the AGR was mild but significantly lower, except in dogs with sarcomas and benign tumors. CONCLUSIONS: In dogs with nasal disease alone, there are usually no marked abnormalities in blood count. However, while mildly increased NLR and decreased AGR can be observed in almost all NPs, an increased PLR may indicate a malignant NP and can be used as an additional screening tool in dogs with nasal discharge due to nasal cavity pathology.


Assuntos
Carcinoma , Doenças do Cão , Globulinas , Rinite , Sarcoma , Cães , Animais , Neutrófilos/patologia , Cavidade Nasal/patologia , Estudos Prospectivos , Rinite/diagnóstico , Rinite/microbiologia , Rinite/veterinária , Linfócitos , Mucosa Nasal , Sarcoma/diagnóstico , Sarcoma/veterinária , Albuminas , Carcinoma/veterinária , Estudos Retrospectivos , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/microbiologia
15.
Vet Med Sci ; 10(2): e1383, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38379264

RESUMO

A 15-year-old Cocker Spaniel was referred to for the evaluation of left forelimb lameness. Radiographic and computed tomography examinations revealed osteolysis of the proximal left third, fourth and fifth metacarpal bones and pathological fractures of the proximal left fourth metacarpal bone. Histopathological examination via bone biopsy did not provide a definitive diagnosis, and the owner elected limb-sparing surgery. The fourth metacarpal bone and digits were amputated. Subsequently, autologous bone grafts were performed on the lytic area of the third and fifth metacarpal bones. The dog showed improvement in gait 7 weeks after reconstructive surgery. Chronic non-bacterial osteomyelitis (CNO) was diagnosed by exclusion. To the best of our knowledge, CNO has not been previously reported in dogs.


Assuntos
Doenças do Cão , Osteomielite , Cirurgia Plástica , Cães , Animais , Tomografia Computadorizada por Raios X/veterinária , Osteomielite/cirurgia , Osteomielite/veterinária , Osteomielite/microbiologia , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia , Doenças do Cão/patologia
16.
BMC Vet Res ; 20(1): 52, 2024 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-38341543

RESUMO

BACKGROUND: Tracheal collapse (TC), a common disease in dogs, is characterized by cough; however, little is known about the serum biomarkers that can objectively evaluate the severity of cough in canine TC. Furthermore, studies elucidating the relationship of fluoroscopic characteristics with the severity of cough are lacking. Therefore, this study aimed to evaluate the relationship between cough severity and clinical characteristics, fluoroscopic images, and new serum biomarkers in canine TC. RESULTS: Fifty-one client-owned dogs diagnosed with TC based on fluoroscopic and clinical signs were enrolled in this study and divided into three groups according to the severity of cough (grade of cough: 0, 1, and 2). Signalments, comorbidities, and fluoroscopic characteristics were compared among the groups retrospectively. The serum matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-6), surfactant protein-A (SP-A), and syndecan-1 (SDC-1) levels were measured in all groups. No significant differences in age, breed, sex, or clinical history were observed among the groups. Concomitant pharyngeal collapse increased significantly with the severity of cough (p = .031). Based on the fluoroscopic characteristics, the TC grade of the carinal region increased significantly and consistently with the grade of cough (p = .03). The serum MMP-9 level was significantly higher in the grade 2 group than that in the grade 0 group (p = .014). The serum IL-6 level was significantly lower in the grade 1 group than that in the grade 0 group (p = .020). The serum SP-A and SDC-1 levels did not differ significantly among the groups. CONCLUSIONS: The severity of cough with the progression of TC can be predicted with the fluoroscopic TC grade at the carinal region. MMP-9 may be used as an objective serum biomarker that represents cough severity to understand the pathogenesis.


Assuntos
Doenças do Cão , Metaloproteinase 9 da Matriz , Humanos , Cães , Animais , Estudos Transversais , Estudos Retrospectivos , Interleucina-6 , Tosse/veterinária , Biomarcadores , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/etiologia
17.
Vet Med Sci ; 10(2): e1375, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38358057

RESUMO

A 2-year-old Pomeranian-Spitz dog (5.8 kg) was admitted with symptoms of uterine prolapse and lethargy 1 day after whelping three puppies. The prolapsed uterus was corrected, but the next day, prolapse reoccurred. To fix the cervix to the abdominal wall, the dog underwent a surgery operation where intussusception in the left horn of the uterus was found. Ovariohysterectomy was performed as the treatment of choice. The diagnosis of intussusception is challenging, and exploratory laparotomy is the reliable diagnostic approach. Although uterine intussusception is rare, it should be one of the important considerations in dogs within the post-partum period.


Assuntos
Doenças do Cão , Intussuscepção , Prolapso Uterino , Feminino , Cães , Animais , Intussuscepção/diagnóstico , Intussuscepção/cirurgia , Intussuscepção/veterinária , Útero/cirurgia , Histerectomia/veterinária , Prolapso Uterino/cirurgia , Prolapso Uterino/veterinária , Período Pós-Parto , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia
18.
Vet Med Sci ; 10(2): e1377, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38358058

RESUMO

Two surgically treated haematomyelia cases were documented. One dog and one cat were presented for acute progressive paraplegia following a fall from height incident. Neurological examinations suggested a L4-S3 myelopathy in both cases. Radiography and magnetic resonance imaging in both cases revealed no fracture or subluxation of the spine, but well-defined intramedullary mass lesions in lower lumbar regions compatible with haemorrhage and haematoma formation. Exploratory surgeries were performed over the lesions. Dark-red friable masses were removed via myelotomy. Histopathological examinations revealed organizing haematomas at the acute to subacute stage. Postoperatively, both cases improved and regained ambulation. The dog walked normally but remained urinary and faecal incontinent 9 months after the surgery. The cat was continent and ambulatory with a paraparetic gait 5 months after the surgery. In both cases, the outcomes and the patients' quality of life were considered satisfactory by the owners.


Assuntos
Doenças do Cão , Doenças da Medula Espinal , Doenças Vasculares da Medula Espinal , Cães , Animais , Qualidade de Vida , Doenças da Medula Espinal/etiologia , Doenças da Medula Espinal/cirurgia , Doenças da Medula Espinal/veterinária , Imageamento por Ressonância Magnética/veterinária , Doenças Vasculares da Medula Espinal/complicações , Doenças Vasculares da Medula Espinal/veterinária , Resultado do Tratamento , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/etiologia
19.
Can Vet J ; 65(2): 119-124, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38304473

RESUMO

An 8-month-old female Maltese dog was referred for examination with a history of circling, dullness, and drooling. Serum biochemical analysis revealed hyperammonemia, with microhepatica observed on radiography. Computed tomography angiography revealed a portosystemic shunt originating from the right gastric vein and inserting into the prehepatic caudal vena cava. Portal blood flow to the liver was not observed. Based on computed tomography angiography, the dog was tentatively diagnosed with portosystemic shunt with portal vein aplasia. An exploratory laparotomy was done to obtain a definitive diagnosis. The dog had no subjective clinical signs of portal hypertension during a temporary occlusion test of the portosystemic shunt. A thin-film band was placed around the portosystemic shunt to achieve partial attenuation. There was no evidence of hepatic encephalopathy in the long term after surgery, and the dog's liver volume increased over time. Computed tomography angiography at 6 mo after surgery identified well-visualized intrahepatic portal branches. Key clinical message: We inferred that a direct occlusion test is a reliable diagnostic technique that overcomes the limitations of diagnostic imaging methods, including computed tomography angiography, and is a good technique for determining whether surgical attenuation is possible in dogs with suspected portal vein aplasia.


Atténuation chirurgicale réussie d'un shunt porto-systémique chez un chien avec une aplasie de la veine porte diagnostiquée par imagerie. Une femelle bichon maltais âgée de 8 mois a été référée pour examen avec une histoire de tournis, apathie et salivation excessive. L'analyse biochimique du sérum a révélé une hyperammionémie, avec un petit foie observé lors des radiographies. Une angiographie par tomodensitométrie a révélé un shunt porto-systémique prenant son origine de la veine gastrique droite et s'insérant dans la veine cave caudale pré-hépatique. Le flot sanguin porte au foie n'était pas observé. Sur la base de l'angiographie par tomodensitométrie, un diagnostic présumé de shunt porto-systémique avec aplasie de la veine porte a été émis. Une laparotomie exploratoire a été effectuée afin d'obtenir un diagnostic définitif. Le chien ne présentait pas de signe clinique subjectif d'hypertension portale durant un test d'occlusion temporaire du shunt porto-systémique. Une bande de film mince a été placée autour du shunt porto-systémique pour causer une réduction partielle. Il n'y avait aucune évidence d'encéphalopathie hépatique à long terme après la chirurgie, et le volume du foie du chien a augmenté dans le temps. Une angiographie par tomodensitométrie effectuée 6 mo après la chirurgie a permis de bien visualiser des branches portes intra-hépatiques.Message clinique clé :Nous avons déduit qu'un test d'occlusion est une technique diagnostique fiable qui surpasse les limites des méthodes d'imagerie diagnostique, incluant l'angiographie par tomodensitométrie, et est une bonne technique pour déterminer si une réduction chirurgicale est possible chez des chiens chez qui on soupçonne une aplasie de la veine porte.(Traduit par Dr Serge Messier).


Assuntos
Doenças do Cão , Derivação Portossistêmica Transjugular Intra-Hepática , Cães , Feminino , Animais , Veia Porta/diagnóstico por imagem , Veia Porta/cirurgia , Veia Porta/anormalidades , Derivação Portossistêmica Transjugular Intra-Hepática/veterinária , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia , Fígado/diagnóstico por imagem , Fígado/cirurgia , Angiografia/métodos , Angiografia/veterinária
20.
Can Vet J ; 65(2): 173-176, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38304476

RESUMO

Objective: To describe a case of small intestinal obstruction secondary to kinetic sand ingestion in a dog. Animal: An 11-year-old neutered male shih tzu dog with a 2-day history of anorexia. Procedure: Abdominal radiographs revealed a small intestinal bowel loop dilated with radiopaque material, consistent with sand ingestion. The dog's only sand exposure was to kinetic sand. After 8 h of medical management, radiographs were consistent with a small intestinal obstruction. Results: The dog underwent exploratory laparotomy, which revealed distal jejunal and ileal distention with palpable soft foreign material that could not be milked into the colon. The sand was removed through a single enterotomy. The dog was discharged 4 d after surgery. Conclusion and clinical relevance: The hydrophobic properties of kinetic sand may make it more likely than regular sand to cause intestinal obstruction that requires surgery. With the increasing popularity and availability of kinetic sand for domestic use, clinicians should have a high index of suspicion for kinetic sand impaction and secondary intestinal obstruction.


Obstruction du petit intestin à la suite de l'ingestion de sable à modeler (Kinetic Sand) chez un chien. Objectif: Description d'un cas d'obstruction du petit intestin secondaire à l'ingestion de sable à modeler chez un chien. Animal: Chien shih tsu mâle castré âgé de 11 ans avec une historique d'anorexie depuis 2 jours. Procédure: Des radiographies abdominales ont révélé une anse du petit intestin dilatée avec du matériel radio-opaque, compatible avec une ingestion de sable. Une exposition à du sable à modeler était la seule exposition connue pour ce chien. Après 8 h de gestion médicale, les radiographies étaient compatibles avec une obstruction du petit intestin. Résultats: Une laparotomie exploratoire a révélé une distension du jéjunum distal et de l'iléon avec du matériel étranger mou palpable qui ne pouvait être transité dans le côlon. Le sable a été retiré à la suite d'une entérotomie simple. Le chien a obtenu sont congé médical 4 j après la chirurgie. Conclusion et signification clinique: Les propriétés hydrophobes du sable à modeler le rendent plus propice que le sable régulier à causer une obstruction intestinale et de nécessiter une chirurgie. Avec la popularité et disponibilité grandissante du sable à modeler pour usage domestique, les cliniciens devraient avoir un degré élevé de suspicion pour l'impaction par le sable à modeler et l'obstruction intestinale secondaire.(Traduit par Dr Serge Messier).


Assuntos
Doenças do Cão , Obstrução Intestinal , Animais , Cães , Masculino , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/etiologia , Doenças do Cão/cirurgia , Ingestão de Alimentos , Íleo , Obstrução Intestinal/diagnóstico por imagem , Obstrução Intestinal/etiologia , Obstrução Intestinal/cirurgia , Obstrução Intestinal/veterinária , Intestino Delgado/cirurgia , Areia
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